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ea0063p26 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

How do sex and BMI affect glucocorticoid treatment in adrenal insufficiency?

Puglisi Soraya , Tabaro Isabella , Cannavo Salvatore , Borretta Giorgio , Pellegrino Micaela , Chiappo Francesca , Pia Anna , Terzolo Massimo , Reimondo Giuseppe

Background and objective: Optimization of glucocorticoid (GC) replacement therapy in adrenal insufficiency (AI) is crucial to avoid consequences of under- or overtreatment. Dosing of GC replacement is mainly based on clinical grounds; however, the impact of patientÂ’s characteristics on daily GC requirement is poorly evaluated. The aim of the study is to assess the influence of sex (M/F) and BMI on dosing GC in patients with AI of different etiology....